11/18/2023 0 Comments My heritage deep nostalgia apkWGS, WES available on the platform for clinical diagnosticsĬurrently traded companies like 23andMe or MyHeritage with thousands of employees and years on the market have, objectively a high-quality report on ancestry nonetheless, they haven´t innovated to extract as much information as possible from your genetic code. More than 700k markers and Illumina technology Report Design: Educational Example Ancestry report Comparative table of different DNA tests available on the market INFORMATION Regular updates of genetic information based on new research: Information is updated for 3 months and then can be accessed only after subscription. WGS, WES : Does not offer clinical genetic diagnosis AncestryDNA® Traits + Full Access Subscription - 199 $ * with automatic subscription renewed every 3 monthsĪccess and upload of raw data: You can get your Raw data from the platform, however it does not accept Raw data from other companies.World Explorer Membership+Ancestry DNA - 100$ * with 79,95$ automatic subscription renewed every 3 months.DNA Matches (Connect with other people who share your DNA).We base the analysis on Y-DNA (Y Chromosome), mtDNA (mitochondrial DNA), really important to identify haplogroups, and autosomal DNA testing using GSA Array technology from Illumina, that extracts 700,000 markers and with the support of genetic algorithms impute to analyze up to 20M markers that let us provide accurate information about predisposition in many areas. At the end of the article, you will find a comparative table summarizing what each company has to offer.ĪDNTRO is a Spanish company, founded in 2020. We will review the different features of each one, analyzing the reports available, their purchase options and prices, if it is possible to load raw data from other companies, if they offer other services and the way the information is presented (design and user experience). Among the direct-to-consumer DNA tests available in the market, which are the best companies to consider? Some companies have this kind of analysis available like Nebula Genomics and also ADNTRO. We can analyze its complete DNA (3,200,000,000 positions), and together with complex bioinformatic analysis will be a useful information for the doctor for clinical diagnosis. The data obtained will get up to the complete sequencing of the genome (Whole Genome Sequencing). If we want to know which genetic variants might have clinical implications, we will need different technologies: gene panels, whole exome sequencing or whole genome sequencing, depending on the medical purpose. On the other hand, if we go to the clinical area the approach is different. By analyzing those genetic variants, we can provide a polygenic risk score that tells you your genetic predisposition to complex diseases, to metabolize the active principle of medical drugs, to convert beta-carotenes to vitamin A, etc Clinical diagnostic tests At ADNTRO we analyze 700,000 polymorphisms (SNPs) of your DNA by using the "Global Screening Array" or GSA, from the Illumina company together with genetic algorithms that allow us to impute your results and analyze up to 20M markers. The number of genetic variants analyzed change according to the type or DNA microarray. In this array are found the probes that have the complementary sequence of each polymorphism. In order to genotype a DNA array is needed. It identifies small variations in genetic sequence within populations, such as single nucleotide polymorphisms ( SNP). Genetic testing direct to consumersĬompanies such as ADNTRO, 23andMe, MyHeritage, TellmeGen, Ancestry and a few others, base their analysis on genotyping technologies and offer, what is called, direct-to-consumer (DTC) genetic tests that determine differences in genetic complement by comparing the positions of DNA with that of another sample or a reference sequence. Organizing from the less to the more complex technology we can find genotyping, panel of genes, whole exome sequencing and whole genome sequencing. When it comes to genomics, we can find different types of technologies that provide different results. Differences between technologies for genetic analysis
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